LARGE VESSEL = High media cost + Downstream cost + Long sterilization and cooling times + Difficulty in disposing infective material
Head plates are the most expensive part of the vessel and also the component which creates most problems. Head plates on low volume laboratory fermenters/bioreactors have been simply scaled down from larger fermentors.
To setup a fermentation vessel with head plates takes much time and each vessel size requires not only a new head plate but also longer pH and pO2 probes, antifoam and temperature probes and practically everything on the head (O-rings, nuts, lead-throughs,...). This is extremely expensive.
Therefore, very often researchers decide to buy the vessel of largest volume to spare investment money.
However, working with higher than needed volume is also very expensive.
LAMBDA has decided to question the use of head plates and found a very practical, easy-to-use and economical solution instead.