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Bioreactor - Short selection of references

1. Controlled growth of Staphylococcus aureus under various concentrations of BAC (benzalkonium chloride) in MINIFOR fermentor:

Dana Cervinkova, Vladimir Babak, Durdica Marosevic, Iva Kubikova, and Zoran Jaglic. Microbial Drug Resistance. June 2013, 19(3): 160-167. The Role of the qacA Gene in Mediating Resistance to Quaternary Ammonium Compounds
Veterinary Research Institute, Brno, Czech Republic.
Keywords: Staphylococcus aureus, benzalkonium chloride (BAC), exponential phase, expression, real-time PCR, culture, concentration

2. MINIFOR Bioreactors for stem cells:

Shayan, N., Ebrahimi, M., Beiki, B. and Janzamin, E. 2012. A non-rotational, computer-controlled suspension bioreactor for expansion of umbilical cord blood mononuclear cells. BIOTECHNOLOGY LETTERS.
Department of Regenerative Medicine, Cell Research Center, Royan Institute for Stem Cell Biology and Technology, Royan Cord Blood Bank, Tehran, Iran; Department of Stem Cells and Developmental Biology, Cell Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
Keywords: Static culture; Suspension bioreactor; Umbilical cord blood; Vertical mixing

3. Bioreactors - An overview of the innovations implemented in MINIFOR bioreactors:

Lehky, P. 2003. Bioreactors - New Solutions for Old Problems. International Congress on Bioreactor Technology, Tampere, Finland.
Keywords: bioreactor, fermentor, cell culture, DO probe, gas flow-rate, gas station.

4. Anaerobic expression using the LAMBDA MINIFOR:

Park, M. -O., Mizutani, T. and Jones, P. R. 2007. Glyceraldehyde-3-Phosphate Ferredoxin Oxidoreductase from Methanococcus maripaludis. Journal of Bacteriology, Tokyo, Japan.
Fujirebio Incorporated, Japan.

5. pH and temperature continuously recorded with the LAMBDA MINIFOR and SIAM software:

Chaignon, P., Cortial, S., Guerineau, V., Adeline, M. T., Giannotti, C., Fan, G. and Ouazzani, J. 2005. Photochemical Reactivity of Trifluoromethyl Aromatic Amines: The Example of 3,5-diamino-trifluoromethyl-benzene (3,5-DABTF) for Photochem Photobiol.
Institut de Chimie des Substances Naturelles, C.N.R.S, Avenue de la Terrasse, 91198, Gif-sur-Yvette cedex, France.

6. Systems for High-Density Hybridoma Growth and High-yield mAb production in cell culture: Bench-top stirred tank bioreactors, 1-5 L (MINIFOR - LAMBDA Laboratory Instruments)

Gary C. Howard, Matthew R. Kaser. 2013. Making and using antibodies - a practical handbook. CRC Press. Boca Raton.

7. LAMBDA MINIFOR bioreactor to grow the oral bacteria (Streptococcus oralis, Actinomyces naeslundii, Veillonella parvula, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis) under planktonic conditions

Blanc V, Isabal S, Sánchez MC, Llama-Palacios A, Herrera D, Sanz M, León R. Characterization and application of a flow system for in vitro multispecies oral biofilm formation. J Periodont Res 2013;
Journal of Periodontal Research
Keywords: biofilm model; chlorhexidine; confocal laser scanning microscopy; oral bacteria

8. The metabolic stress response of tomato cell culture (Lycopersicum esculentum) to low oxygen studied using LAMBDA MINIFOR Bioreactor

Ampofo-Asiama, J., Baiye, V. M. M., Hertog, M. L. A. T. M., Waelkens, E., Geeraerd, A. H., Nicolai, B. M. (2013), The metabolic response of cultured tomato cells to low oxygen stress. Plant Biology.
German Botanical Society and The Royal Botanical Society of the Netherlands
Keywords:13C label; cell culture; low O2 stress; Lycopersicum esculentum; metabolome

9. LAMBDA MINIFOR Bioreactor used for recombinant protein (Chemokines) expression in E. coli

Birgit Kramp, "Establishing the interaction between the CC chemokine ligand 5 and the receptors CCR1 and CCR5
Fakultät für Mathematik, Informatik und Naturwissenschaften, RWTH Aachen, Belgium
Keywords: CCL5 , CCR1m, Chemokininteraktion, Interaktion

10. Recombinant expression of the Met-CCL5, protease resistant CXCL12 (S4V) and F1-CX3CL1 in E. coli to study their role in Cardiovascular disease (CVD)

Projahn, D., Generation, function and therapeutic application of chemotactic cytokines in cardiovascular diseases
Institut für Molekulare Herz-Kreislaufforschung, Fakultät für Mathematik, Informatik und Naturwissenschaften, RWTH Aachen, Belgium
Keywords: myocardial infarction therapy , Met-CCL5 , protease-resistant CXCL12 , fractalkine antagonist

11. Expression of Caf1 protein using Escherichia coli strain to study mammalian cell adhesion, shape and number of focal adhesion

Machado Roque, A. I., Protein scaffolds for cell culture, 2013
PhD Thesis, Newcastle University

12. Effective production of Biobutanol from agricultural waste (giant hogweed, hay)

Mežule, L., Tihomirova, K., Neščerecka, A., Juhna, T. Biobutanol Production from Agricultural Waste: A Simple Approach for Pre-Treatment and Hydrolysis. Latvian Journal of Chemistry, 2012, 51, pp.407-414.
Riga Technical University, Latvia
Keywords: biofuel, biobutanol, agricultural waste, hydrolysis

13. Bioethanol production using Yeast (S. cerevisiae) in LAMBDA MINIFOR Fermenter

Burešová, I., Hřivna, L., Effect of wheat gluten proteins on bioethanol yield from grain. Applied Energy Volume 88, Issue 4, April 2011, Pages 1205–1210
Agrotest Fyto, Ltd., Kroměříž, Czech Republic; Mendel University in Brno, Brno, Czech Republic
Keywords: Bioethanol; Triticale; Wheat; Gluten; Protein

14. Anaerobic fermentation of the glucose component in dates extract by yeast Saccharomyces cerevisiae

Mohamed H. Gaily, Basheir M. Elhassan, Ahmed E Abasaeed, Saeed M. Al-Zahrani. A Direct Process for the Production of High Fructose Syrups from Dates Extracts; International Journal of Food Engineering. Volume 6, Issue 3, ISSN (Online) 1556-3758
King Saud University, Saudi Arabia; University of Khartoum, Sudan
Keywords: dates, fructose, glucose, ethanol, fermentation, S. Cerevisiae, yeast, mesophilic, batch

15. Selective and non-selective batch fermentation of date extract using Saccharomyces cerevisiae (commercial strain used in bakeries (wild strain), glucose selective strains ATCC 36858 and ATCC 36859) studied using LAMBDA MINIFOR fermentor.

Meilana Dharma Putra, Ahmed E. Abasaeed, Mohamed A. Zeinelabdeen, Mohamed H. Gaily, Ashraf K. Sulieman, Selective fermentation of pitted dates by S. cerevisiae for the production of concentrated fructose syrups and ethanol, Journal of Physics: Conference Series 495 (2014) 012034
Chemical Engineering Department, King Saud University, Saudi Arabia
Keywords: Selective, non-selective, fermentation, yeast, S. cerevisiae, fructose, ethanol, dates, HPLC, kinetic profiles

16. Growing yeast cultures (DBY12007) in MINIFOR at steady state to study the aerobic glycolysis and energy flux

Nikolai Slavov, Bogdan A. Budnik, David Schwab, Edoardo M. Airoldi, and Alexander van Oudenaarden, Constant Growth Rate Can Be Supported by Decreasing Energy Flux and Increasing Aerobic Glycolysis, Cell Reports 7, 705–714, May 8, 2014
Massachusetts Institute of Technology, USA; Harvard University, USA; Hubrecht Institute, Netherlands and Princeton University, USA.
Keywords: Yeast, aerobic glycolysis, exponential growth, O2 consumption, CO2 production, amino acids, mRNAs, proteins, posttranslational modifications, stress sensitivity, respiratory quotient (RQ)

17. Quantification of ribosomal proteins (RPs) from Yeast cells cultured in MINIFOR and mouse embryonic stem cells (ESC) to study the core RPs stoichiometry

Nikolai Slavov, Stefan Semrau, Edoardo Airoldi, Bogdan Budnik, Alexander van Oudenaarden, Variable stoichiometry among core ribosomal proteins, arXiv:1406.0399, Jun 2014.
Harvard University, USA; Broad Institute of MIT and Harvard, USA and Hubrecht Institute, Netherlands.
Keywords: Budding Yeast cells, Embryonic stem cells (ESC), Ribosomal Protein, RP, ribosomes, mRNA, mass-spectrometry, posttranslational modification, PTM

18. Six-species flow cell biofilm model was developed by culturing bacteria in LAMBDA MINIFOR Bioreactor to evaluate the biofilm development under flow and shear conditions

Salli, Krista M., and Arthur C. Ouwehand. The use of in vitro model systems to study dental biofilms associated with caries: a short review. Journal of oral microbiology 7 (2015).
DuPont Nutrition and Health, Kantvik Active Nutrition, Finland.
Keywords: dental caries, batch culture, continuous culture, artificial mouth, flow cell, microcosm

19. Robust cellulosic ethanol production from sugarcane bagasse with Saccharomyces cerevisiae ATCC 20602 in LAMBDA MINIFOR laboratory bioreactor under aerobic and anaerobic conditions with controlled redox potential measurement

Jabasingh, S. Anuradha, D. Lalith, M. Arun Prabhu, Abubekker Yimam, and Taye Zewdu. Catalytic conversion of sugarcane bagasse to cellulosic ethanol: TiO2 coupled nanocellulose as an effective hydrolysis enhancer. Carbohydrate Polymers (2015).
Addis Ababa Institute of Technology, Ethiopia; Sathyabama University, India.
Keywords: Cellulosic ethanol; bagasse; Titanium dioxide; Nanocellulose; Cellulase Saccharomyces cerevisiae

20. S. pyogenes Cas9 protein expressed using a 3L computer-controlled MINIFOR bioreactor in batch medium followed by exponential feeding

Ménoret, Séverine, Anne De Cian, Laurent Tesson, Séverine Remy, Claire Usal, Jean-Baptiste Boulé, Charlotte Boix et al. Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins. Scientific reports5 (2015).
INSERM UMR 1064-ITUN; CNRS UMS3556 Nantes; CNRS UMR7196; Sorbonne Universities; University Pierre & Marie Curie; France.

21. Cultivation of microalgae (Chlorella vulgaris Beyerinck) in laboratory bioreactor MINIFOR

Mikrovetikate Chlorella vulgaris kasvatamise eelkatsed bioreaktoris Lambda Minifor
Heitur, Heiko. "Mikrovetika Chlorella vulgaris Beyerincki kasvatamine CO2 sidumise eesmärgil." PhD diss., 2014. Estonian University of Life Sciences, Estonia.

22. Fermentation of engineered microorganism in laboratory scale bioreactor MINIFOR for efficient conversion of lactose-to-ethanol

Pasotti, Lorenzo, Susanna Zucca, Michela Casanova, Nicolo Politi, Ilaria Massaiu, Giuliano Mazzini, Giuseppina Micoli, Cinzia Calvio, Maria Gabriella Cusella De Angelis, and Paolo Magni. "Methods for genetic optimization of biocatalysts for biofuel production from dairy waste through synthetic biology." In Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE, pp. 953-956. IEEE, 2015.
Department of Electrical, Computer & Biomedical Engineering and Interdepartmental Research Centre for Tissue Engineering, University of Pavia, Italy
Keywords: lactose-to-ethanol conversion; microorganism optimization; synthetic biology; whey protein; permeate; pollutant waste disposal; genetic optimization; green energy production; biofuel production; cheese production process; dairy waste; biocatalyst


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